NoMachine has installations implemented throughout numerous industry sectors, including the fields of technology and communications, in companies such as HP, Google, IBM, Siemens, Motorola, SAP, Philips Semiconductors, Nokia, Verisign, VMWare, Novell, Symbio Technologies, Trolltech, Toshiba Electronics Europe, AXA Technology Services, Wind Telecommunicazioni, H3G Italy; in finance and banking, including BNP Paribas, Nexus Financial, and Great-West Life & Annuity; in transportation and freight, namely, Lufthansa Airlines, Europ Hall, Frans Maas, and All American Moving Group; in healthcare, such as St Jude's Children's Research Hospital, Biofocus, Medtrac, Debio Recherche Pharmaceutique and Labor 28 AG; in retail and manufacturing, such as Hirshfield's Inc, EGS (Groupe Laurent), Les Schwab Tire Centers.

NoMachine's reach is also extended to the fields of government and education which prevail in numbers with customers such as Brookhaven National Laboratory, US Navy, City of Schwaebisch Hall, City of Munich, Yale University, Harvard University, Stanford University, the University of California-Berkeley, the University of Sunderland, Alice Salomon Fachhochscule, and many others.